Bree's injections
Bree's injections became the subject of a great deal of debate since the video House Arrest, in which Bree is wearing a bandage because she had to receive an injection.
These are given to her by her father but he claims that he does not know what they contain. Fans have long speculated on the contents and purpose of these injections, but it still remains unclear.
Contents
Vitamin B-12
For a long time the leading theory was that the injections contained vitamin B-12 to stimulate blood production. If this were the case, Bree's participation in the ceremony would likely involve blood being drawn from her. Bree's preparation for the ceremony also requires her to take iron supplements, which also aid in the production of blood. In this sense, it's logical to think that the shots may contain vitamin B-12. However, Bree has described that these shots often leave her feeling unwell, which should not be the case if they are merely vitamin B12 supplements.
Cerebyx® and Zosyn®
After Daniel posted the video Back At Bree's, fans began to analyse his clip for clues about Bree's ceremony. Two pamphlets caught viewers' eyes. They were on what seemed to be Bree's parents' bed. As Daniel was exploring, he panned his camera across the bed, producing only some blurry shots of the covers of these pamphlets. Fans claim to have identified that they are informative pamphlets for the drugs Cerebyx® and Zosyn®. Cerebyx® is an anticonvulsive medication that has had some experimental testing as a pain medication.<ref>Wikipedia article on Cerebyx®</ref> Zosyn® is an antibiotic.<ref>Wikipedia article on Zosyn®</ref>
At the end of his video, Daniel said he had found something, but he does not reveal what it was. Many viewers thought he would eventually reveal these pamphlets. In his next video, Undisclosed Location, Daniel explains that what he found was a box with a lemniscate imprinted on it. Once he showed that it was the box that held significance to him, the pamphlets became of less importance. It is unlikely that he would have noticed the box and not the pamphlets, so it's likely that he saw them but did not think they were important. Bree's father is a doctor, and as such probably has many more marketing materials from drug companies strewn about the bedroom other than the ones seen in the video.
It should also be kept in mind that Daniel is filming in a real home. As such, there are things in the house that belong to the true owners of the house. It is known that the house is owned by a friend of one of the creators and he is a doctor himself. This was revealed in a YouTube fan video when Calphillips knocked on the door and began to question the man who owned the house. There is a very real possibility that these pamphlets are literature present for the usage of the actual owner of the house.
EPOGEN®
Daniel finds boxes of EPOGEN® in a warehouse that he visits in his video Breaking And Entering. He believes the warehouse belongs to a company where Bree's father used to work. Daniel found out about this company after he explored Bree's house and came across a box with a lemniscate symbol imprinted on it. When he finds a room in the warehouse filled with these boxes, he opens one to find packets of EPOGEN®. He immediately suspects that Bree's injections must have contained this drug and later does some research on it. Daniel's findings leave him confused as to why Bree would be given this substance. Interestingly, he doesn't seem to consider the possibility that this is just one of the many medications stored in this company's warehouse.
EPOGEN® is an injectable drug for the treatment of anemia. It contains epoetin alfa, a man-made version of erythropoietin, which is a protein produced naturally for the production of red blood cells. It is produced through recombinant DNA technology. EPOGEN® therapy may increase the risk of seizures, thrombotic events, and other serious events. The most commonly reported side effects in clinical trials were hypertension, headache, arthralgias, and nausea.<ref name=EPOGEN>Wikipedia article on EPOGEN®</ref>
EPOGEN® is meant for use in patients with chronic renal failure on dialysis.<ref name=EPOGEN/> Bree does not fit this profile, which indicates that she must not be receiving the drug merely because she is anemic, but rather because there is a serious need to increase her red blood cell count for some other reason. This usage might suggest preparation for a blood-letting ritual in the ceremony (as in the case of Vitamin B-12). The Iron pills would also help her in this regard. The risk of seizures brought on by use of EPOGEN® could explain why Bree's parents had information on Cerebyx on hand (and possibly some in stock). The side effects of EPOGEN® would also explain why Bree says that her injections don't always leave her feeling the best.
Other suggestions
Viewers have also suspected that the injections contain mood-altering drugs.
References
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